Endocrine Abstracts

Tumours of the pituitary gland and sellar region represent approximately 15% of all brain tumours. The most common tumours are by far pituitary adenomas, confined to the sella. However, several types of tumours may involve the sellar region, reflecting its complex anatomy. The differential diagnosis of nonpituitary sellar masses is broad and includes inflammatory and infectious diseases, cell rest tumours, germ cell tumours, lipomas, gliomas, meningiomas, metastatic tumours, a...

There are a wide range of tests to measure insulin sensitivity. Alternative techniques for estimating insulin sensitivity include measurements made during the oral glucose tolerance test (OGTT). We aimed to describe the weekly intraindividual daily variability of measures of insulin sensitivity indexes (HOMA-IR, QUICKI, Matsuda’s insulin sensitivity index (ISIM), Insulinogenic Index, Early C Peptide, Stumvoll’s Insulin Sensitivity Index (ISIS), OGIS_120)...

The prevalence of obesity markedly increased in the last 2 decades. This have asserted researchers’ attention to the role of adipose tissue throughout the pathophysiology process of a number of diseases. Fatness, namely abdominal fat, is a risk for insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Physical activity is recommended as one of treatment options for individuals with T2DM. This study aimed to determine the relationship between in...

Introduction: The pseudohypoparathyroidism (PHP) encompasses a heterogeneous group of diseases characterized by end-organ resistance to parathyroid hormone (PTH). PHB type 1b (PHP1b) presents with PTH resistance at the renal proximal tubule, sometimes with TSH resistance, usually in the absence of Albright’s hereditary osteodystrophy (AHO) clinical features.Case report: A 64-year-old male was referred to endocrinology department for hypocalcemia. He...

Introduction: Arthropathy affects the majority of acromegalic patients and is a major cause of morbidity, absenteeism and impaired quality of life. GH excess and increased levels of circulating IGFI result initially in a marked thickening of the soft tissues and cartilage. Along with disease progression, there’s subperiostal bone neoapposition, cartilage regressive phenomena and bone structural changes. We aimed to investigate prevalence, clinical presentation, treatment ...

Introduction: Post-surgical hypoparathyroidism is a well known complication of total thyroidectomy. It may occur as transitory hypoparathyroidism that spontaneously recover within a few weeks/months and as permanent hypoparathyroidism needing long-term treatment. Only few cases of hypoparathyroidism newly diagnosed many years after surgery have been reported. We present a patient with hypoparathyroidism that became clinically evident 15 years after the thyroid surgery.<p c...

Introduction: LH receptor plays an important role in sexual development and reproductive function. Mutations of this receptor lead to the development of three clinical conditions: Leydig cell hypoplasia, hypergonadotropic hypogonadism with primary amenorrhea and familial male limited precocious puberty. The first two entities result from inactivating mutations. In Leydig cell hypoplasia, with autosomal recessive inheritance, the phenotypic spectrum correlates with the degree o...

Background: Generously supported by IPSEN)-->Pituitary abscess is a rare but potentially fatal entity. It represents ~0.2–1% of all pituitary lesions. The symptoms are usually nonspecific. The proper interpretation of imaging studies is of extreme importance to the differential diagnoses.Case: Man, 40 years old, begins complaining of occipital headache (25.04.2011), initially with good response to treatmen...

Introduction: Obesity is nowadays one of the most important challenges in public health and, therefore, the investigation of their causes is most relevant. Among the various behavioral roots of obesity, the emotional over ingestion determined by emotional factors, i.e. emotional eating (EE), is one of them.Objectives: To study how emotions contribute to obesity in woman.Methods: We gathered a convenience sample 220 woman in the hos...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...